The computer mouse is 40 years old...

 Here's a demo film from 1968 showing one of the first computer mice...I love the peculiar combined keyboard/mouse pad that resembles an airline meal tray.

[video:http://uk.youtube.com/watch?v=1MPJZ6M52dI&feature=related 425x344] 

Quis custodiet ipsos custodes?

So, who watches the Internet Watch Foundation watchmen?  Wikipedia entry "Quis custodiet ipsos custodes?".

A ZDnet article says "Wind up the Internet Watch Foundation"...

And presumably the four wise people at the IWF who carefully study potentially illegal images and websites (and of course bad taste 70s LP sleeves) have some kind of internet exemption...

Oliver Postgate RIP

Very sad news- Oliver Postgate, the man responsible for many remarkably excellent childrens' TV shows has died.  There's a concise biography at wikipedia.

My particular favorite show was Noggin the Nog, but I expect many of us of a certain age will feel nostalgic over one or more of his TV shows.  He'll be missed.


In the Journals - The strange origin of the Drosophila Y chromosome

ResearchBlogging.org

The Y chromosome in Drosophila is a strange thing, and it has several unique features.  While, just as in humans, male flies are XY and females XX, flies differ in the the Y chomosome doesn't determine "maleness".  Rather the sex of the fly is determined by the ratio of X chromosomes to the number of sets of autosomes (the X:A ratio).  If the X:A ratio is 1, then the fly is female, if it is 0.5, the fly is male.  So an X0 fly (i.e. one with a single X chromosome with no Y chromosome) develops as a male.  [This can be quite useful in the laboratory] What then is the Y chromosome for?  It is required for male fertility but not viability.  This means that XY flies are fertile males, XX fies are fertile females, XXY flies are fertile females and X0 flies are sterile males.

One might expect then that whatever genes are located on the Y chromosome are related mainly to fertility, or are genetically redundant.  In fact there are very few known genes on the Drosophila melanogaster Y chromosome - 12, in fact, and many if not all are related to fertility in males.  12 genes is really not many for a chromosome, and it turns out that the Y chromosome is pretty much composed of genetically inert heterochromatin and largely comprises simple sequence repetitive DNA.  

 The figure below (source) shows male (a) and female (b) karyotypes.  The Y chromosome is labelled in (a) - notice that it stains particularly darkly.

The highly repetitive nature of the Y chromosome means that the Y chromosome sequences of the 12 sequenced Drosophila species are less complete that the sequences of the other chromosomes. Of these, perhaps the best quality is that of the Drosophila melanogaster Y chromosome, for which the catalogue of genes is thought to be complete.  This paper compares the D. melanogaster Y chromosome with those of the other 11 sequences species of Drosophila.  Note that the two closely related species persimilis and pseudoobscura differ from the others in that the Y chromosome became part of an autosome in that lineage.  The pattern of acquisition of the D. melanogaster Y chromosomal genes is shown in the diagram below:

 The red arrows indicate acquisition of genes on the Y (these are found on autosomes or X chromosome in the other species); FDY is a special case, and resulted from a duplication of an autosomal gene in the melanogaster lineage after it split from the simulans lineage.  Presumably the other Y chromosome lineages show acquired loci.

The data presented here don't support specific hypotheses as to why genes move to the Y at such frequency.  However, it seems clear that a chromosome with so few genes, but with a high rate of gene acquisition must be evolutionarily young.

 

 

Leonardo B. Koerich, Xiaoyun Wang, Andrew G. Clark, Antonio Bernardo Carvalho (2008). Low conservation of gene content in the Drosophila Y chromosome Nature DOI: 10.1038/nature07463

Wacky Jacqui's plan to stop ID card leaks leaked!

The Sunday Times reports that our authoritarian Home Secretary's plans to prevent leaks from the companies working on implemented the expensive and unnecessary ID card scheme has itself been leaked.

What's particularly draconian is that it seems the desire is to implement a system whereby workers at these companies may have their homes searched without needing  a search warrant.

The Home Office said the proposals in the document aimed to keep the identity card scheme secure and did not introduce new legal powers.

However, Shami Chakrabarti, director of Liberty, the civil rights group, said: "This reveals the extent of Home Office arrogance and contempt for individual privacy.

"It's not enough constantly to legislate our liberty away - now it seems they want companies and employees to contract out of legal rights not to have private security guards trampling through their premises without a warrant."

This is, of course, hot on the heels of the dubious anti-terror police search of Conservative MP Damian Green' offices at the Houses of Parliament, a search made in an investigation of leaks from the Home Office, and one which Jacqui Smith denies all knowledge.