Of the many questions in evolutionary biology, the genetic basis of reproductive isolation between species and subspecies is a pretty hot topic. Drosophila pseudoobscura is a new world Drosophila species that has been used in evolutionary biology studies for many years. This paper looks at the genetic basis of the hybrid sterility and segregation distortion seen in crosses between two subspecies, D. pseudoobscura pseudoobscura (referred to as "USA") and D. pseudoobscura bogotana (referred to as "Bogota"). It's a nice illustration of the impact of the 12 Drosophila genome sequences now available - D. pseudoobscura was the second Drosophila species to have its genome sequenced.
There is only partial reproductive isolation between these subspecies - male progeny from Bogota females crossed with USA males are virtually sterile (though when aged, they apparently yield offspring, though with a distorted sex ratio indicative of segregation distortion). The female siblings are fertile, as are the offspring of a cross performed between UAS females crossed with Bogota males. The two subspecies therefore obey Haldane's Rule.