- The utilization during mitotic cell division of loci controlling meiotic recombination and disjunction in Drosophila melanogaster.
- Bruce S. Baker, Adelaide T. C. Carpenter, and P. Ripoll
- Genetics 1978 90: 531-578. [Abstract] [PDF]
As a postdoc, I worked for several years on the cell cycle in Drosophila. At that time, the field was just beginning to take off, not least because of the efforts of my then group leader. Nowadays, I study the ageing process, still using Drosophila, and including modelling the function of WRN, the gene responsible for the progeroid condition Werner's syndrome (WS). WRN encodes a RecQ DNA helicase (unwinds the DNA double helix), but unusually has a second activity, a DNA exonuclease (removes nucleotide bases from the end of a DNA strand). We are currently studing the Drosophila homologue of the WRN exonuclease (which we have named DmWRNexo, and which is encoded by the CG7670 locus).
When trying to demonstrate that a mutant of CG76700 indeed displayed characteristic comparable with defects seen in cell lines derived from WS patients, I recalled reading this paper at the beginning of my postdoc position.